COVID-19: the new immune challenge

Do you want to know more about Coronavirus infection? What has actually happened and why now? How big is the virus? How does it harm people? Where did the virus come from, and how did it spread to humans? Or maybe you want to know how your body defends itself from the virus. Well, you can find the answers to all these questions in this short article. We hope you will enjoy reading

Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors

Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but their impact on disease progression remains unknown. We have found in aged Apoe−/− mice that artery TLOs (ATLOs) controlled highly territorialized aorta T cell responses. ATLOs promoted T cell recruitment, primed CD4+ T cells, generated CD4+, CD8+, T regulatory (Treg) effector and central memory cells, converted naive CD4+ T cells into induced Treg cells, and presented antigen by an unusual set of dendritic cells and B cells. Meanwhile, vascular smooth muscle cell lymphotoxin β receptors (VSMC-LTβRs) protected against atherosclerosis by maintaining structure, cellularity, and size of ATLOs though VSMC-LTβRs did not affect secondary lymphoid organs: Atherosclerosis was markedly exacerbated in Apoe−/−Ltbr−/− and to a similar extent in aged Apoe−/−Ltbrfl/flTagln-cre mice. These data support the conclusion that the immune system employs ATLOs to organize aorta T cell homeostasis during aging and that VSMC-LTβRs participate in atherosclerosis protection via ATLOs

Loop mediated isothermal amplification as a powerful tool for early diagnosis of hepatitis C virus

Data associated with the paper, "Paper microfluidic implementation of loop mediated isothermal amplification for early diagnosis of hepatitis C virus.